1 Hypothalamic gonadotropin releasing hormone ( GnRH ) receptor neurons fire in 2 synchrony with the female reproductive cycle 3 4 Abbreviated title : 5
نویسندگان
چکیده
1 Hypothalamic gonadotropin releasing hormone (GnRH) receptor neurons fire in 2 synchrony with the female reproductive cycle 3 4 Abbreviated title: 5 GnRHR neuron activity during the estrous cycle 6 7 8 9 10 Christian Schauer1, Tong Tong1, Hugues Petitjean1, Thomas Blum1, Sophie Peron1, 11 Oliver Mai, Frank Schmitz, Ulrich Boehm, and Trese Leinders-Zufall 12 13 Department of Physiology and Center for Integrative Physiology and Molecular Medicine, 14 Department of Pharmacology and Toxicology, and 15 Department of Anatomy, University of Saarland School of Medicine, 66421 Homburg, Germany 16 17 18 19 20 Correspondence to Trese Leinders-Zufall, University of Saarland School of Medicine, Center for 21 Integrative Physiology and Molecular Medicine, Building 48, 66421 Homburg, Germany; email: 22 [email protected] or Ulrich Boehm, University of Saarland School of Medicine, Department of 23 Pharmacology and Toxicology, Building 61.4, 66421 Homburg, Germany; email: 24 [email protected] 25 26 Articles in PresS. J Neurophysiol (June 10, 2015). doi:10.1152/jn.00357.2015
منابع مشابه
Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle.
Gonadotropin-releasing hormone (GnRH) controls mammalian reproduction via the hypothalamic-pituitary-gonadal (hpg) axis, acting on gonadotrope cells in the pituitary gland that express the GnRH receptor (GnRHR). Cells expressing the GnRHR have also been identified in the brain. However, the mechanism by which GnRH acts on these potential target cells remains poorly understood due to the difficu...
متن کاملSocial regulation of the electrical properties of gonadotropin-releasing hormone neurons in a cichlid fish (Astatotilapia burtoni) 1 Short title: Electrical properties of cichlid GnRH neurons Key Words: Behavior, Gonadotropin-releasing hormone, Neuroendocrine
1 Short title: Electrical properties of cichlid GnRH neurons Abstract 1 Variation in reproductive capacity is common across the lives of all animals. In 2 vertebrates, hypothalamic neurons that secrete gonadotropin-releasing hormone (GnRH) are a 3 primary mediator of such reproductive plasticity. Since social interactions suppress gonadal 4 maturity in the African cichlid fish, Astatotilapia (H...
متن کاملHypothalamic Expression of Melanocortin-4 Receptor and Agouti-related Peptide mRNAs During the Estrous Cycle of Rats
Melanocortin- 4 receptor (MC4R) and agouti- related peptide (AgRP) are involved in energy homeostasis in rats. According to MC4R and AgRP effects on luteinizing hormone (LH) secretion, they may influence the estrous cycle of rats. Therefore, the aim of this study was to investigate the expression of MC4R and AgRP mRNAs at different stages of estrous cycle in the rat’s hypothalamus. The estrous ...
متن کاملInsulin Receptor Signaling in the GnRH Neuron Plays a Role in the Abnormal GnRH Pulsatility of Obese Female Mice
Infertility associated with obesity is characterized by abnormal hormone release from reproductive tissues in the hypothalamus, pituitary, and ovary. These tissues maintain insulin sensitivity upon peripheral insulin resistance. Insulin receptor signaling may play a role in the dysregulation of gonadotropin-releasing hormone (GnRH) secretion in obesity, but the interdependence of hormone secret...
متن کاملP-95: Seasonal Changes in Hypothalamic Gonadotropin-Inhibitory Hormone Expression in Alectoris Chukar
Background Gonadotropin-inhibitory hormone (GnIH), initially discovered in birds as a hypothalamic neuropeptide, inhibits the synthesis and release of gonadotropins via affecting GnRH neurons and gonadotropes. Therefore, it could be a key neuropeptide in regulating seasonal breeding in birds. The aim of the present study was to investigate the expression of GnIH in the hypothalamus of male and ...
متن کامل